Pediatric Grand Rounds

1. Recognize the critical role of the emergency room physician in acute management of VOC in children with SCD;
2. Describe key components of a standardized pain protocol;
3. Recall the nuances and correlation between pain scores, frequency of assessment and analgesia selection;
4. Identity the effects of a patent ductus arteriosus on the premature infant;
5. Review the risks and benefits of surgical PDA ligation vs percutaneous PDA closure;
6. Introduce the phenomenon of post-PDA ligation syndrome and understand its physiologic basis;
7. Recall the role of the proposed BTK-BCAP-PI3K interaction in Ras signaling as it pertains to pathophysiology of JMML;
8. Recognize the potential efficacy of combined inhibition of BTK and PI3Kp110d in ameliorating JMML phenotypes in an in vivo mouse model;
9. Recognize the role of combined inhibition of BTK and PI3Kp110d in promoting megakaryopoeisis and depressing monocytopoeisis towards correction of JMML phenotypes;
10. Identitify how a mutation in the DNA repair mechanism can cause increased sensitivity to chemotherapy;
11. Recognize how colony forming assays and Western blots can help determine cell survival and protein expression after ionizing radiation; and
12. Appreciate how a laboratory experiment can be translated to the bedside to help answer a clinical question.

Accreditation Statement

In support of improving patient care, Indiana University School of Medicine is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physicians

Indiana University School of Medicine designates this enduring activity for a maximum of 1.00 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

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