Fundamentals of Early Onset Alzheimer's Disease- Part 2

Friday, May 27, 2022, 12:00 PM - Saturday, May 27, 2023, 11:59 AM

This 4-part series is designed for family medicine practitioners. Part 1 is a review of assessment and diagnosis of Alzheimer's disease. Part 2 is an introduction to early onset Alzheimer's disease (Alzheimer's disease with symptom onset before age 65). Part 3 covers Alzheimer's disease in traditionally underserved groups and the importance of diverse representation in research. Finally, Part 4 is a brief overview of biomarkers and their use in the early detection of Alzheimer's disease. Faculty from the Indiana University School of Medicine and the Indiana Alzheimer's Disease Research Center (IADRC) will share their expertise with course participants on these topics.

Launch Date: 5/27/2022

Expiration Date: 5/27/2023

1. Differentiate normal cognitive aging from mild cognitive impairment from dementia
2. Identify next steps and appropriate referrals for further workup of memory problems when Alzheimer's disease is suspected
3. Describe early onset Alzheimer's disease and its atypical variant presentations
4. Recognize symptoms that differentiate early onset Alzheimer's disease from psychiatric conditions (which reduce misdaignosis)
5. Characterize the risk of Alzheimer's disease for Black/AA and Latino/a Americans
6. List at least three factors to keep in mind when inviting individuals from traditionally underserved groups to participate in research
7. Explain how inclusion of biomarkers into the NIA-AA criteria for dementia and MCI due to probable Alzheimer's disease improves diagnostic accuracy
8. Identify and describe at least three biomarker methods for Alzheimer's disease and their level of specificity for disease detection

 

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·       Crutch, S.J., et al., Consensus classification of posterior cortical atrophy. Alzheimers Dement, 2017. 13(8): p. 870-884

·       Filley, C.M., J. Kelly, and R.K. Heaton, Neuropsychologic features of early- and late-onset Alzheimer's disease. Arch Neurol, 1986. 43(6): p. 574-6. 

·       Fujimori, M., et al., Age at onset and visuocognitive disturbances in Alzheimer disease. Alzheimer Dis Assoc Disord, 1998. 12(3): p. 163-6.

·       Jacobs, D., et al., Age at onset of Alzheimer's disease: Relation to pattern of cognitive dysfunction and rate of decline. Neurology, 1994. 44: p. 1215-1220. 

·       Koedam, E. L., et al. (2010). Early-versus late-onset Alzheimer's disease: more than age alone. Journal of Alzheimer's Disease, 19(4), 1401-1408. 

·       Koss, E., et al., Clinical and neuropsychological differences between patients with earlier and later onset of Alzheimer's disease: A CERAD analysis, Part XII. Neurology, 1996. 46(1): p. 136-41.

·       Loring, D.W. and J.W. Largen, Neuropsychological patterns of presenile and senile dementia of the Alzheimer type. Neuropsychologia, 1985. 23(3): p. 351-7. 

·       Mendez, M.F., et al., Clinicopathologic differences among patients with behavioral variant frontotemporal dementia. Neurology, 2013. 80(6): p. 561-8

·       Ossenkoppele, R., et al., The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features. Brain, 2015. 138(Pt 9): p. 2732-49. 

·       Ossenkoppele, R., et al., Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis. JAMA, 2015. 313(19): p. 1939-49

·       Owens, T.E., et al., Patterns of Neuropsychological Dysfunction and Cortical Volume Changes in Logopenic Aphasia. J Alzheimers Dis, 2018. 66(3): p. 1015-1025. 

·       Seltzer, B. and I. Sherwin, A comparison of clinical features in early- and late-onset primary degenerative dementia. One entity or two? Arch Neurol, 1983. 40(3): p. 143-6.

·       Townley, R.A., et al., Progressive dysexecutive syndrome due to Alzheimer’s disease: a description of 55 cases and comparison to other phenotypes. Brain communications, 2020. 2(1): p. fcaa068

For questions about accessibility or to request accommodations please contact the IUSM CME office at 317-274-0104 or [email protected] One week advance notice will allow us to provide seamless access. Please ensure to specify the accommodations you need in order to participate.

AMA PRA Category 1 Credits™ (0.50 hours), Non-Physician Attendance (0.50 hours)

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Indiana University School of Medicine, Continuing Medical Education adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CE activity, including faculty, planners, reviewers or others are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.