Fundamentals of Early Onset Alzheimer's Disease- Part 4

Friday, May 27, 2022, 12:00 PM - Saturday, May 27, 2023, 11:59 AM

This 4-part series is designed for family medicine practitioners. Part 1 is a review of assessment and diagnosis of Alzheimer's disease. Part 2 is an introduction to early onset Alzheimer's disease (Alzheimer's disease with symptom onset before age 65). Part 3 covers Alzheimer's disease in traditionally underserved groups and the importance of diverse representation in research. Finally, Part 4 is a brief overview of biomarkers and their use in the early detection of Alzheimer's disease. Faculty from the Indiana University School of Medicine and the Indiana Alzheimer's Disease Research Center (IADRC) will share their expertise with course participants on these topics.

Launch Date: 5/27/2022

Expiration Date: 5/27/2023

1. Differentiate normal cognitive aging from mild cognitive impairment from dementia
2. Identify next steps and appropriate referrals for further workup of memory problems when Alzheimer's disease is suspected
3. Describe early onset Alzheimer's disease and its atypical variant presentations
4. Recognize symptoms that differentiate early onset Alzheimer's disease from psychiatric conditions (which reduce misdaignosis)
5. Characterize the risk of Alzheimer's disease for Black/AA and Latino/a Americans
6. List at least three factors to keep in mind when inviting individuals from traditionally underserved groups to participate in research
7. Explain how inclusion of biomarkers into the NIA-AA criteria for dementia and MCI due to probable Alzheimer's disease improves diagnostic accuracy
8. Identify and describe at least three biomarker methods for Alzheimer's disease and their level of specificity for disease detection

 

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Physicians
Indiana University School of Medicine designates this  enduring activity for a maximum of 0.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

·       Albert MS, DeKosky ST, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011;7(3):270–279. doi:10.1016/j.jalz.2011.03.008

·       Apostolova LG, et al. The Longitudinal Early-onset Alzheimer’s Disease Study (LEADS): Framework and Methodology. Alzheimers Dement. 2021, in press. doi: 10.1002/alz.12350. 

·       Blennow K, Zetterberg H. Biomarkers for Alzheimer's disease: current status and prospects for the future. J Intern Med. 2018;284(6):643–663. doi:10.1111/joim.12816

·       Crutch SJ, Schott JM, Rabinovici GD, et al. Consensus classification of posterior cortical atrophy. Alzheimers Dement. 2017;13(8):870–884. doi:10.1016/j.jalz.2017.01.014

·       Engelborghs S, Le Bastard N. The impact of cerebrospinal fluid biomarkers on the diagnosis of Alzheimer's disease. Mol Diagn Ther. 2012;16(3):135–141. doi:10.1007/bf03262201

·       Jack CR Jr, Albert MS, Knopman DS, et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011;7(3):257–262. doi:10.1016/j.jalz.2011.03.004

·       Jack CR Jr, Bennett DA, Blennow K, et al. NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease. Alzheimers Dement. 2018;14(4):535–562. doi:10.1016/j.jalz.2018.02.018

·       Li X, Zhang ZJ. Neuropsychological and neuroimaging characteristics of amnestic mild cognitive impairment subtypes: a selective overview. CNS Neurosci Ther. 2015;21(10):776–783. doi:10.1111/cns.12391

·       McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34(7):939–944. doi:10.1212/wnl.34.7.939

·       McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011;7(3):263–269. doi:10.1016/j.jalz.2011.03.005

·       Petersen RC, Caracciolo B, Brayne C, Gauthier S, Jelic V, Fratiglioni L. Mild cognitive impairment: a concept in evolution. J Intern Med. 2014;275(3):214–228. doi:10.1111/joim.12190

·       Preiß D, Billette OV, Schneider A, Spotorno N, Nestor PJ. The atrophy pattern in Alzheimer-related PPA is more widespread than that of the frontotemporal lobar degeneration associated variants. Neuroimage Clin. 2019;24:101994. doi:10.1016/j.nicl.2019.101994

·       Rabinovici et al. Association of Amyloid Positron Emission Tomography With Subsequent Change in Clinical Management Among Medicare Beneficiaries With Mild Cognitive Impairment or Dementia. JAMA 2019; 321:1286-1294.

 

For questions about accessibility or to request accommodations please contact the IUSM CME office at 317-274-0104 or [email protected]. One week advance notice will allow us to provide seamless access. Please ensure to specify the accommodations you need in order to participate.

AMA PRA Category 1 Credits™ (0.50 hours), Non-Physician Attendance (0.50 hours)

Mitigation of Relevant Financial Relationships

Indiana University School of Medicine, Continuing Medical Education adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CE activity, including faculty, planners, reviewers or others are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.