Promoting Medication Adherence in Pediatric Populations

Wednesday, September 19, 2018, 12:00 AM - Thursday, September 19, 2019, 12:00 AM

Pediatric Grand Rounds

1. Describe the prevalence and implications of pediatric medication non-adherence;
2. Implement adherence assessment strategies in clinical practice; and
3. Identify appropriate behavioral interventions to target common barriers to medication adherence.

Accreditation Statement

In support of improving patient care, Indiana University School of Medicine is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physicians

Indiana University School of Medicine designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

References for this presentation:

Bhatia et al. Nonadherence to oral mercaptopurine and risk of relapse in Hispanic and Non-Hispanic white children with acute lymphoblastic leukemia: A report from the Children’s Oncology Group. J Clin Oncol. 2012;30:2094-2101.Bhatia et al. Systematic exposure to thiopurines and risk of relapse in children with acute lymphoblastic leukemia: A Children’s Oncology Group study. JAMA Oncol. 2015;1:287-295.DiMatteo. Variations in patients’ adherence to medical recommendations: A quantitative review of 50 years of research. Med Care. 2004;42:200-209.Centers for Medicare and Medicaid Services. National Health Expenditure Data. https://www.cms.gov/Research-Statistics-Data-and-Systems/Statistics-Trends-and-Reports/NationalHealthExpendData/NationalHealthAccountsHistorical.html. Accessed August 8, 2018.Finney et al. The overestimation of adherence to pediatric medical regimens. Child Health Care. 1993;22:297-304Jarzembowski et al. Impact of non-compliance on outcome after pediatric kidney transplantation: An analysis in racial subgroups. Pediatr Transplant. 2004;8:367-371Kato et al. A video game improves behavioral outcomes in adolescents and young adults with cancer: A randomized trial. Pediatrics. 2008;122:e305-317.Kennard et al. Nonadherence in adolescent oncology patients: Preliminary data on psychological risk factors and relationships to outcomes. J Clin Psychol Med Settings. 2013;11:31-39.Landier et al. Comparison of self-report and electronic monitoring of 6MP intake in childhood ALL: a Children's Oncology Group study. Blood. 2017;129:1919-1926.McGrady et al. An independent evaluation of the accuracy and usability of electronic adherence monitoring devices. Ann Intern Med. 2018;epub 22 May 2018.McGrady et al. Cost-effectiveness analysis of an adherence-promotion intervention for children with leukemia: A Markov model-based simulation. J Pediatr Psychol. 2018;43:758-768McGrady et al. Topical review: Theoretical frameworks in pediatric adherence-promotion interventions: Research findings and methodological implications. J Pediatr Psychol. 2015;40:721-726.Modi et al. Pediatric self-management: A framework for research, practice, and policy. Pediatrics. 2011;129:e473.Pai & McGrady. Assessing medication adherence as a standard of care in pediatric oncology. Pediatr Blood Cancer. 2015;62:S818-S828.Pai & McGrady. Systematic review and meta-analysis of psychological interventions to promote treatment adherence in children, adolescents, and young adults with chronic illness. J Pediatr Psychol. 2014;39:918-931.Pai et al. Correspondence between objective and subjective reports of adherence among adolescents with acute lymphoblastic leukemia. Child Health Care. 2008;37:225-235.Quittner et al. Evidence-based assessment of adherence to medical treatments in pediatric psychology. J Pediatr Psychol. 2008;33:916-936.Rapoff MA. Adherence to Pediatric Medical Regimens. New York, NY: Springer;2011.Simons & Blount. Identifying barriers to medication adherence in adolescent transplant recipients. J Pediatr Psychol. 2007;32:831-844.Tilson HH. Adherence or compliance? Changes in terminology. Ann Pharmacother. 2004;38:161-162Walter et al. Assessing adherence to oral chemotherapy using different measurement methods: Lessons learned from capecitabine. J Oncol Pharm Pract. 2014;20:249-256.World Health Organization. Adherence to Long-Term Therapies: Evidence for Action. Geneva: World Health Organization; 2003.Wu & Pai. Health care provider-delivered adherence promotion interventions: A meta-analysis. Pediatrics. 2014;133:e1698-e1707.Zelikovsky et al. Eliciting accurate reports of adherence in a clinical interview: Development of the Medical Adherence Measure. Pediatr Nurs. 2008;34:141-146.

For questions about accessibility or to request accommodations please contact the CME office at 317-274-0104 or cme@iu.edu. One week advance notice will allow us to provide seamless access. Please ensure to specify the accommodations you need in order to participate.

AMA PRA Category 1 Credits™ (1.00 hours), Non-Physician Attendance (1.00 hours)

In accordance with the Accreditation Council for Continuing Medical Education (ACCME) Standards for Commercial Support, educational programs sponsored by the Indiana University School of Medicine (IUSM) must demonstrate balance, independence, objectivity, and scientific rigor. All faculty, authors, editors, and planning committee members participating in an IUSM-sponsored activity are required to disclose any relevant financial interest or other relationship with the manufacturer(s) of any commercial product(s) and/or provider(s) of commercial services that are discussed in an educational activity.